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Writer's pictureRyan Sheridan, NP

Magnesium for Depression, Anxiety, and Sleep: A Guide for Magnesium Supplementation


Food with magnesium

In this blog post we will discuss all things magnesium! Magnesium is frequently praised for its calming effects on stress and mood. Despite its reputation, many people either take insufficient doses or opt for magnesium forms that the body doesn’t easily absorb. Consequently, they might not see the desired improvements in their anxiety, stress levels, mood, or sleep quality.


I get questions all the time in my practice as an integrative psychiatric nurse practitioner in Washington, DC. Let's go over some of the frequently asked questions to help you understand magnesium and its potential role for you.


What are the Impacts of Magnesium on Mental Health?


Magnesium plays a crucial role in maintaining mental health and emotional well-being. Here’s how it impacts mental health:


1. Regulation of Neurotransmitters: Magnesium helps regulate neurotransmitters, the chemicals that transmit signals in the brain. It inhibits the release of excitatory neurotransmitters like glutamate, which can overstimulate the brain and lead to anxiety. By doing so, magnesium promotes a state of calm and balance, which can reduce feelings of anxiety and stress.


2. Stress Response Modulation: Magnesium is involved in regulating the body’s stress response, particularly by controlling the release of cortisol, the primary stress hormone. Elevated cortisol levels can contribute to feelings of anxiety, depression, and fatigue. Magnesium helps keep cortisol levels in check, reducing the overall stress load on the body and brain.


3. Sleep Support: Magnesium influences sleep by activating the parasympathetic nervous system, which is responsible for helping the body relax. It also binds to GABA (gamma-aminobutyric acid) receptors, a neurotransmitter that promotes sleep and relaxation. Adequate magnesium levels can improve sleep quality, reduce insomnia, and alleviate symptoms of restless sleep.


4. Mood Regulation: Low levels of magnesium have been linked to an increased risk of depression. Magnesium supports the production of serotonin, often referred to as the “feel-good” hormone, which plays a significant role in mood regulation. By ensuring adequate magnesium intake, you may experience a more stable and positive mood.


5. Reduction of Physical Symptoms: Magnesium also helps alleviate physical symptoms that can contribute to mental distress, such as headaches, muscle tension, and fatigue. By addressing these physical issues, magnesium indirectly supports better mental health.


Overall, maintaining sufficient magnesium levels is essential for reducing stress, anxiety, depression, and improving sleep, all of which are critical components of mental health.


In summary, magnesium can positively impact:


• Increased stress

• Depression

• Sleep disturbances or insomnia

• Headaches or muscle tension

• Fatigue


Which foods have the highest levels of magnesium?


Magnesium is found in a variety of foods, particularly those that are whole and unprocessed. And because it is always best to get our nutrients from (quality) food, let's go over some of the foods that are richest in magnesium:


Green leafy vegetables

1. Leafy Green Vegetables: Dark, leafy greens like spinach, kale, and Swiss chard are excellent sources of magnesium. Just one cup of cooked spinach provides about 157 mg of magnesium, making it one of the most magnesium-rich vegetables.


2. Nuts and Seeds: Nuts such as almonds, cashews, and Brazil nuts, along with seeds like pumpkin, chia, and flaxseeds, are packed with magnesium. For example, a one-ounce serving of almonds contains about 80 mg of magnesium.


3. Legumes: Beans, lentils, chickpeas, and soybeans are all good sources of magnesium. Black beans, for instance, provide around 120 mg of magnesium per cup.


4. Whole Grains: Whole grains like quinoa, brown rice, oats, and barley are high in magnesium. Quinoa, in particular, contains about 118 mg of magnesium per cooked cup.


5. Fish: Certain types of fish, especially fatty fish like salmon, mackerel, and halibut, are good sources of magnesium. A serving of mackerel can provide around 82 mg of magnesium.


6. Avocado: This nutrient-dense fruit is rich in magnesium, with one medium avocado offering around 58 mg.


7. Dark Chocolate: High-quality dark chocolate is not only a treat but also a good source of magnesium. One ounce of dark chocolate (70-85% cocoa) contains about 64 mg of magnesium.


8. Bananas: While better known for their potassium content, bananas also provide a decent amount of magnesium—about 32 mg per medium-sized banana.


9. Tofu: Tofu, a popular plant-based protein, is also a good source of magnesium. A half-cup serving contains about 37 mg of magnesium.


10. Dairy Products: Some dairy products, such as yogurt and milk, also contain magnesium, although in smaller amounts compared to the other sources.


Including a variety of these foods in your diet can help ensure you meet your daily magnesium needs and support overall health.


Is Getting Enough Magnesium from Food Possible?


While a balanced diet is the foundation for increasing your mineral intake, it may not be sufficient for everyone, particularly those with mental health conditions. Here’s why:


1. Modern Agricultural Practices: The way we cultivate food today has significantly reduced the mineral content in soil, including magnesium. Additionally, food processing methods can strip away up to 80% of the magnesium content in foods, making it harder to get enough from diet alone.


2. Individual Nutritional Needs: Each person’s magnesium requirements can vary due to factors like genetics, metabolism, and existing health conditions. Individuals dealing with anxiety, depression, or insomnia often have higher magnesium needs, which may be difficult to meet through diet alone.


Because of these factors, some people may need to consider magnesium supplements to ensure they get the amount they need for optimal mental and physical health.


What are the Best Forms of Magnesium for Anxiety, Depression, and Sleep?

Magnesium supplements

The most commonly prescribed forms of magnesium—magnesium oxide and magnesium citrate—tend to have the lowest bioavailability. This means they are more likely to pass through the gut without being fully absorbed, often leading to loose stools or diarrhea. These forms are more suitable for relieving constipation rather than addressing mental health issues. Similarly, magnesium salts like carbonate and sulfate face absorption challenges.


Recent studies highlight certain forms of magnesium with better bioavailability and ability to cross the blood-brain barrier, making them more effective for treating symptoms of anxiety, depression, and sleep disorders:


1. Magnesium Taurate


Best for: Anxiety and Overall Mental Health

Why: Magnesium taurate combines magnesium with taurine, an amino acid known for its calming, neuroprotective, and anti-inflammatory effects on the brain. Taurine also appears to facilitate the entry of magnesium into the brain. Additionally, this form is gentle on the gastrointestinal tract, reducing the risk of digestive side effects like diarrhea. Recent research shows that magnesium acetyl taurate can increase brain magnesium levels more effectively than other forms.


2. Magnesium Threonate


Best for: Cognitive Function and Depression

Why: Magnesium threonate has strong scientific backing for its effectiveness in mental health conditions, particularly because it can cross the blood-brain barrier. This form has shown promise in improving cognitive function and mood, making it a good option for those dealing with depression. However, it can be more expensive and may require taking multiple capsules to achieve a therapeutic dose.


3. Magnesium Glycinate


Best for: Sleep and Anxiety

Why: Magnesium glycinate combines magnesium with glycine, an amino acid that acts as a neurotransmitter in the brain. Glycine is known for its ability to improve sleep quality, making this form of magnesium ideal for those with insomnia. Preliminary research suggests that magnesium glycinate can increase brain magnesium levels, and like magnesium taurate, it is gentle on the GI tract, minimizing digestive discomfort.


4. Magnesium Malate


Best for: Energy Production and Chronic Fatigue

Why: Magnesium malate is one of the more easily absorbed forms of magnesium, effectively raising both serum and muscle magnesium levels. Preliminary studies indicate that it may be beneficial in treating symptoms of fibromyalgia and chronic fatigue, as malate plays a role in energy production.


Extra Credit: When choosing a form of magnesium to address mental health concerns like anxiety, depression, or sleep disturbances, two key factors should be considered:


1. Bioavailability: This refers to how much magnesium can be absorbed by the gut and utilized by the body.


2. Brain Access: Effective forms of magnesium must be able to cross the blood-brain barrier to exert their effects on the brain.


Based on current research, magnesium taurate and magnesium glycinate have the strongest evidence supporting their effectiveness in treating anxiety and other mental health disorders. Magnesium malate and magnesium threonate also show therapeutic potential and may be valuable options in managing psychiatric conditions. By choosing the right form of magnesium, individuals can better target their specific mental health needs and achieve more effective results.


Incorporating a variety of magnesium types into your routine can be highly beneficial because different forms of magnesium offer unique benefits and absorption properties. For instance, magnesium glycinate is excellent for promoting relaxation and improving sleep, while magnesium threonate is particularly effective in enhancing cognitive function due to its ability to cross the blood-brain barrier. Magnesium malate supports energy production, making it ideal for combating fatigue, and magnesium taurate provides neuroprotective effects, which can help with anxiety. By using a combination of these forms, you can target multiple aspects of health, ensuring that your body and brain receive comprehensive support.


Alert! I recommend avoiding supplements that have added sugars, flavors, or otherwise. Refined sugar is certainly a no-no before bed. Fruit chews and other candy based supplements usually don't have enough of the good stuff anyway!


How much magnesium do I need for anxiety, depression, or sleep?

Magnesium supplement

The recommended dosage of magnesium for managing anxiety, depression, or sleep issues can vary based on individual needs and the specific form of magnesium being used. However, general guidelines suggest:


For Anxiety: A daily dosage of 200-400 mg of elemental magnesium is commonly recommended. This can help reduce anxiety symptoms and promote relaxation. It’s often taken in divided doses throughout the day or as a single dose in the evening.


For Depression: Similar to anxiety, 200-400 mg per day is typically suggested. Some studies have shown that higher doses, up to 500 mg daily, can be beneficial for mood regulation, but it’s important to start with a lower dose and adjust based on response and tolerance.


For Sleep: For improving sleep quality and reducing insomnia, 300-400 mg of magnesium taken about 30 minutes to an hour before bedtime is generally recommended. Forms like magnesium glycinate are particularly effective for sleep due to their calming properties.


While most supplement labels and nutritional guidelines recommend around 320 mg of magnesium daily—based on the FDA’s recommended dietary allowance for healthy individuals—this amount doesn’t account for the unique biochemical needs or preexisting mental health conditions of individuals.


For instance, a recent study conducted used 1800 mg of magnesium threonate in older patients to assess its impact on executive functioning and memory, indicating that higher doses might be beneficial in specific cases. However, it’s important to recognize that taking too much magnesium can be harmful; another study has found that doses exceeding 2500 mg could lead to toxic or overload of magnesium in the body.


It’s important to consult with a healthcare provider before starting magnesium supplementation, especially at higher doses, to ensure it’s appropriate for your individual needs and won’t interfere with any existing conditions or medications.


Are there side effects to magnesium supplementation?


Magnesium supplementation is generally considered safe for most people when taken within recommended dosages, but like any supplement, it can have potential side effects and risks, especially at higher doses or for certain individuals. Here’s what you need to know:


Common Side Effects


Digestive Issues: The most common side effects of magnesium supplementation include digestive issues such as diarrhea, nausea, and stomach cramps. These symptoms are more likely with forms of magnesium that are less well-absorbed by the body, like magnesium oxide or citrate, which can act as a laxative.


Low Blood Pressure: Magnesium has a natural calming effect on the body, which can lower blood pressure. While this can be beneficial for those with hypertension, it might be a concern for individuals who already have low blood pressure.


Serious Side Effects (Rare)


Hypermagnesemia: Excessive magnesium intake, particularly from supplements, can lead to hypermagnesemia, a condition characterized by abnormally high levels of magnesium in the blood. Symptoms may include low blood pressure, irregular heartbeat, difficulty breathing, and, in severe cases, cardiac arrest. This condition is more likely to occur in individuals with kidney dysfunction, as the kidneys are responsible for excreting excess magnesium.


Interactions with Medications: Magnesium supplements can interact with certain medications, such as antibiotics, diuretics, and heart medications, potentially reducing the effectiveness of the medications or leading to adverse effects.


Safety Considerations


Consulting a Healthcare Provider: It’s important to consult with a healthcare provider before starting magnesium supplementation, especially if you have existing health conditions, are pregnant or breastfeeding, or are taking other medications. Your healthcare provider can help determine the appropriate dosage and form of magnesium for your specific needs.


Dosage Limits: While moderate supplementation (typically up to 400 mg per day) is safe for most people, higher doses should only be taken under medical supervision. The European Commission advises that doses exceeding 2500 mg per day could lead to toxicity.


In summary, magnesium supplementation is generally safe and well-tolerated when taken within recommended limits. However, potential side effects, particularly digestive issues, and interactions with medications should be considered. Always consult with a healthcare provider before beginning supplementation to ensure it is appropriate for your individual health needs.


Choosing the right type of Magnesium

Choosing the right form and dose of magnesium is essential, much like selecting the correct tool for a specific job. When crafting a treatment plan, it’s crucial to rely on the most effective options available. Current research suggests that magnesium taurate and magnesium glycinate are among the top choices for supporting mental health. For those dealing with psychiatric conditions, higher magnesium intake might be necessary compared to the general population, but it’s important to consult with a healthcare provider if you plan to exceed the FDA’s recommended dosage.


Magnesium should be integrated into a holistic approach that includes a balanced diet, stress management practices, and addressing the underlying causes of your symptoms. We hope this guidance empowers you to create a solid foundation for your health journey.


How Does Integrative Psychiatry Test for Magnesium and Addresses Root Causes?


In integrative psychiatry, the approach to mental health is comprehensive, focusing not only on symptoms but also on underlying causes, such as nutrient deficiencies like magnesium deficiency. Here’s how magnesium levels are assessed and how this approach fits into a broader, root-cause-focused treatment strategy.

Lab test tubes

Testing for Magnesium Levels


Integrative providers often begin with a thorough assessment that includes testing for various biomarkers, including magnesium levels. The following methods are commonly used:


1. Serum Magnesium Test: This is the most basic test, measuring the amount of magnesium in the blood. However, since only about 1% of the body’s magnesium is in the bloodstream, this test might not fully reflect total body magnesium levels.


2. Red Blood Cell (RBC) Magnesium Test: This test measures the magnesium content within red blood cells, providing a more accurate picture of long-term magnesium status compared to serum magnesium tests.


3. Magnesium Load Test: Sometimes, a magnesium load or challenge test is used, where magnesium is administered, and then urinary excretion is measured. This test helps determine how much magnesium the body retains, offering insights into magnesium deficiency.


4. Hair Tissue Mineral Analysis (HTMA): This is an alternative method that some integrative practitioners use to assess mineral levels, including magnesium, in the hair. It provides a longer-term view of magnesium status in the body.


Addressing Magnesium Deficiency and Root Causes


Integrative psychiatry looks beyond symptoms to identify and address the root causes of mental health conditions. Magnesium deficiency is one such potential root cause, particularly relevant in cases of anxiety, depression, insomnia, and other mood disorders. Here’s how it fits into a holistic treatment plan:


1. Comprehensive Nutritional Assessment: Beyond just testing for magnesium, integrative psychiatrists often evaluate overall nutritional status, including other minerals, vitamins, and nutrients that are crucial for brain function and mental health.


2. Individualized Treatment Plans: If a magnesium deficiency is identified, the treatment plan is tailored to the individual. This might involve dietary changes to increase magnesium intake from foods, such as leafy greens, nuts, and seeds, as well as targeted supplementation with the appropriate form of magnesium (e.g., glycinate, taurate).


3. Holistic Approach: Magnesium supplementation is not seen as a stand-alone solution. Integrative psychiatry incorporates magnesium into a broader strategy that includes stress management techniques, lifestyle modifications, and addressing other potential root causes, such as hormonal imbalances, gut health issues, and chronic inflammation.


4. Monitoring and Adjusting: Treatment is dynamic, with ongoing monitoring of magnesium levels and overall health to adjust the plan as needed. This ensures that the underlying causes are effectively addressed and that mental health improves in a sustainable way.


By testing for magnesium and considering it as part of the root-cause approach, integrative psychiatry aims to create a more complete and personalized treatment plan. This approach not only alleviates symptoms but also promotes long-term mental and physical well-being.


If you’re struggling with anxiety, depression, or sleep issues, it could be more than just the surface symptoms—nutrient deficiencies like magnesium might be playing a significant role.


As an integrative psychiatric nurse practitioner in Washington, DC, I specialize in uncovering and addressing the root causes of mental health conditions through personalized, holistic care. By utilizing comprehensive testing and tailored treatment plans, we can work together to optimize your mental and physical well-being.

Ryan Sheridan, NP

Take the first step towards a healthier, more balanced life. Book an appointment today and start your journey to wellness with integrative psychiatry.

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